ПАТО-ФИЗИОЛОГИЧЕСКАЯ ЗНАЧИМОСТЬ, РОЛЬ И ТЕРАПЕВТИЧЕСКИЙ ПОТЕНЦИАЛ ЭКЗОСОМ ПРИ ИШЕМИЧЕСКОМ ИНСУЛЬТЕ – НОВЫЙ ПОДХОД К ПОСТИНСУЛЬНОЙ РЕАБИЛИТАЦИИ
Annotatsiya
Ischemic stroke is a leading cause of long-term disability in the world, with limited effective treatments. Increasing evidence demonstrates that exosomes are involved in ischemic pathology and exhibit restorative therapeutic effects by mediating cell–cell communication. The potential of exosome therapy for ischemic stroke has been actively investigated in the past decade. In this review, we mainly discuss the current knowledge of therapeutic applications of exosomes from different cell types, different exosomal administration routes, and current advances of exosome tracking and targeting in ischemic stroke. We also briefly summarized the pathology of ischemic stroke, exosome biogenesis, exosome profile changes after stroke as well as registered potentional role of exosome- based therapy.