Synthesis of tritium labeled Boc‐[Nle<sup>11</sup>] ‐substance P<sub>5</sub>‐11
Naoki SasakiInstitute of Natural Substance Chemistry, C.N.R.SR. MichelotInstitute of Natural Substance Chemistry, C.N.R.SJ.L. MorgatBiochemistry Section, Department of Biology, C.E.A. Saclay, Gif-sur-Yvette, FranceRoger GenetBiochemistry Section, Department of Biology, C.E.A. Saclay, Gif-sur-Yvette, FrancePierre PotìerInstitute of Natural Substance Chemistry, C.N.R.S
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An optically active, alkynyl analogue of norleucine (Nle), L‐2‐amino‐4‐hexynoic acid (Aha), was substituted for Met in the solution synthesis of the Boc‐protected C ‐terminal heptapeptide analogue of substance P. Treatment of the resulting alkynyl peptide with tritium gas in the presence of 10% Pd/C afforded a Boc‐(Nle 11 )‐substance P 5 ‐11 with a specific radioactivity of 96 Ci/mmol.
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