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[Anti-inflammatory effect of fensulkal].

Zakirov AuSultanov Research Institute of Pharmaceutical Chemistry, ul. F. Khodzhaeva 40, Tashkent, 700187 UzbekistanKarshiev DnAzizov UmLeont'eva Li
PubMedrepository2001en
ABI

Annotatsiya

Experiments on various animals showed that fensulkal, a new phenylglyoxylic acid derivative, possesses a high antiinflammatory activity and low toxicity, markedly exceeding butadion in the therapeutic index. The mechanism of the antiphlogistic effect of fensulkal is due to its antagonism with respect to mediators of the inflammatory process and the ability of suppressing the increased permeability of capillaries and is partly related to the adrenal cortex. The drug is registered and recommended for application as antiinflammatory remedy in the form of ointment to be used for the treatment of some gynecological disorders.

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