The influence of nebivolol on 24-hour rhythm, miocardial mass and patients life?s quality in men with arterial hypertension
Annotatsiya
The aim of this study is to evaluate the influence of Nebivolol on 24-hour rhythm, left ventricular's miocardial mass and life's quality in hypertensive patients. 42 men (aged 30-65 years old) with mild and moderate arterial hypertension (AH) were examined. Nebivolol was administrated in dosage of 5 mg once daily as a monotherapy during 6 months. All of parameters was assessed before and after therapy. Also we carried out dynamic control of Blood Pressure (BP) every 2 weeks. We estimated the left ventricular mass with echocardiography by Penn Convention method, carried out 24-hour monitoring of BP and evaluated patient's life's quality. In the result of Nebivolol's monotherapy the left ventricular's miocardial mass was decreased significantly, BP monitoring data showed significant great BP level (BPL) in hypertensives, with more increasing of night-BPL in patients with AH (78.6±5.3% and 75.6±6.3%, p<0.01). We must admit, that the indexes of patients life's quality were improved considerably, in particular the common and psychological condition, the duration and intensity of heart's pain tachicardia were reduced, but Nebivolol exerted influence on sexual inclination and satisfaction to improve them. Thus, the results of our investigation demonstrated, that Nebivolol reduced systolic and diastolic BP effectively, decreased miocardial mass significantly, and also had positive influence on 24-hour BP rhythm and improved life's quality, particularly human's general state and sexual function.