Chitosan-silica nanocomposite sorbent for thin-layer chromatography of alkaloids

The feasibility of using a chitosan-silica nanocomposite sorbent in thin-layer chromatography of cytisine alkaloid and some of its derivatives was studied. The derivatives were obtained by the reactions of cytisine with aromatic aldehydes containing the -OH, -OCH3, and -Br functional groups as substituents in different benzene ring positions. The separation of cytisine and its derivatives on the chitosan-silica sorbent was more effective than on initial silica gel. The mechanism of chromatographing on the two sorbents was considered; the mobile phase was a 6:1 (v/v) chloroform:methanol mixture.

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