A study on the effect of substitutions and intermolecular interactions in thiophene 3-carboxamides
M.K. KokilaM.S. Ramaiah Institute of Technology, MSRIT Post, Bangalore, Karnataka, 560054, India.,PuttarajaG. N. Anil KumarM.S. Ramaiah Institute of Technology, MSRIT Post, Bangalore, Karnataka, 560054, India.,Krishna KumarDepartment of Engineering Physics, HKBK College of Engineering, Nagawara, Arabic College Post, Bangalore, Karnataka, 560045, India,S. MohanM.S. Ramaiah Institute of Technology, MSRIT Post, Bangalore, Karnataka, 560054, India.,J. SaravananPES College of Pharmacy, Hanumanthanagar, Bangalore, Karnataka, 560050, India.,Μ. V. KulkarniDepartment of Chemistry, Karnatak University, Dharwad, Karnataka, 580020, India, E-mail
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6 1 inflammatory, antihistaminic and analgesic activities. Moreover, recently, it was found that some bis-(2-aryl-4-oxothiazolidin-3yl)ethanes act as good cyclooxygenase-2 inhibitory agents. The crystallographic characterization of the bis-heterocycle 1,4-bis-(2phenyl-4-oxo-1,3-thiazolidin-3-yl)butane belonging to a family of compounds synthesized through a one pot three component condensation methodology, with acetonitrile as solvent a r e r e p o r t e d h e r e i n . T h i s compound crystallizes in a monoclinic cell with the cell parameters a=5.7452A(11), b=27.065A(5) c=7.1157A( Space group P21/c [No 14], V = 1066.05A3 and Z= 2.
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