MATHEMATICAL AND COMPUTER MODELLING REGULATORY MECHANISMS FOR PROGRAMMED CELL DEATH (APOPTOSIS)
Annotatsiya
The system for removing needless cells (programmed cell death apoptosis) is important in coordination of structural-functional organisation of large number of cells in an organism. Discovery of cells suicide phenomenon has allowed revising old notions about regulation mechanisms of cellular homeostasis and importance of this mechanisms disturbance during development of large number of diseases including cancer, auto-immune diseases and infection processes. Intuitive understanding activity of the regulatory system connected by means of complex interaction mechanisms between positive and negative feedback loops is very difficult. Here it is necessary formal mathematical methods and computer tools for modelling corresponding regulatory mechanisms. This work deals with some results of the quantitative analysis of simplest regulatory mechanisms for apoptosis process based on the methods for mathematical modeling and computer simulation.