A Study of the Mechanisms of Chloroquine Retinopathy
T.A. IvaninaHelmholtz Institute of Ophthalmology, USSR Academy of Science, MoscowН. Л. СакинаInstitute of Chemical Physics, USSR Academy of Science;M. N. LebedevaMartsinovsky Institute for Medical Parasitology and Tropical Medicine;V.L. BorovyaginInstitute of Biological Physics, USSR Academy of Science, Pushino, Moscow Region, USSR
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The influence of chloroquine on lipid peroxidation in rat and rabbit retinas has been studied. Chloroquine retinopathy is not followed by an increase in lipid peroxidation, and the antioxidant ionol does not prevent the drug effect. Chloroquine has an inhibitory action on induced lipid peroxidation.
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