The Synthesis of a Kind of Dipeptide(In Chinese)

The research on novel radioiodopharmaceutical which treat tumor efficiently is meaningful,moreover,this result just base on the synthesis of the prodrug of radiopharmaceutical.About 85%of malignacy express positive for telomerase. It aims to search for a kind of new compound,which can restrain telomerase and therapy tumor.In this work,a novel prodrug of radioiodopharmaceutical (C_6H_4IPOClNH(CH_2)_6NH-Leu-Gly-Boc) had been designed and synthesized. Some important inter-mediates also had been synthesized.The compound had been analysed using E.S.,~1HNMR(D_2O,200 MHz) and ESI-MS.The results indicated that the synthesis was successful.C_6H_4IPOC1NH(CH_2)_6NH-Leu -Gly-Boc was synthesised from liquid phase instead of trational state phase, which would reduce the cost and improve the maneuverability.

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