Synthesis, Structure, and Biological Activity of Cinnamoyl-Containing Cytisine and Anabasine Alkaloids Derivatives
О. А. НуркеновInstitute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, ul. Alikhanova 1, Karaganda, 100008, KazakhstanZh.S. NurmaganbetovInstitute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, ul. Alikhanova 1, Karaganda, 100008, KazakhstanТ. М. СейлхановSh. Ualikhanov Kokshetau State University, Kokshetau, KazakhstanС. Д. ФазыловInstitute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, ul. Alikhanova 1, Karaganda, 100008, KazakhstanZh. B. SatpayevaInstitute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, ul. Alikhanova 1, Karaganda, 100008, KazakhstanК. М. ТурдыбековE.A. Buketov Karaganda State University, Karaganda, KazakhstanS. A. TalipovA.S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, Tashkent, UzbekistanR. B. Seydakhmetova
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The reactions of the cytisine and anabasine alkaloids with cinnamic acid chloride have been studied, and hydrazinolysis of the resulting N-cinnamoylcytisine and N-cinnamoylanabazine has been carried out. The reaction of cinnamoyl isothiocyanate with alkaloids has afforded the corresponding thiourea derivatives. Antimicrobial and cytotoxic activity of cinnamoyl-containing derivatives of these alkaloids has been evaluated.
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