[The detection of proteomic markers and immunologic profile and their relationship with metabolic parameters in patients with gout.]

The actual concept of gout comprises both traditional metabolic theory of disorder of purine metabolism and external medium impact and involvement of immune inflammatory, genetic and proteomic factors. The proteomic study of patients with tofus gout and patients with asymptomatic hyperiricosuria was carried out using technique of fluid chromatography with mass-spectrometry and immunologic profiling. The specific proteomic markers of gout such as circulating interleukin-8 (IL-8)/CXCL8 and associated heterodimeric complex of myeloid-bound proteins MRP8/MRP14 (kalgranulin A/B) were established. The positive correlation was established concerning shifting of metabolic indices - components of lipid spectrum and level of uric acid both in patients with tofus gout and in lesser degree in patients with asymptomatic hyperiricosuria. It is proposed to consider biomarkers IL-8 and MRP8/MRP14 as independent predictor of development of metabolic shifting and cardiovascular pathology in patients with gout.

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