P2‐305: HIGHER CORTICAL FUNCTIONS EVALUATION STUDY IN PATIENTS WITH ALZHEIMER'S DISEASE IN UZBEKISTAN
Annotatsiya
Higher cortical functions dedicated study in patients with Alzheimer's Disease (AD) has not previously studied in Uzbekistan. We aimed to evaluate the effectiveness of diagnostic disorders of higher cortical functions in patients with AD using scales GDR (Global Deterioration Rating) and MMSE (Mini Mental Scale Examination). Study involved 52 patients (32 men and 20 women) aged 65 to 77 years (mean age 70,8 ± 3,3 years) divided into 2 groups: group 1 (basic group) - AD 45 patients, group 2 (comparison group) - 27 patients with chronic cerebral ischemia (II- IIIst.) with mild cognitive impairment. GDR and MMSE were used for assessing the severity of cognitive impairment. Neuropsychological studies showed the results of cognitive functions: in group I - GDR 5,0 ± 0,5 scores, MMSE 21,8 ± 4,05 scores. In group II - GDR 2,0 ± 0,5 scores, MMSE 27,0 ± 0,5 scores. Senile dementia develops in commonly characterized by a relatively sparse confabulation products. Confabulation shifted to a more or less distant past ideas about the environmental situation and the self (amnestic confabulation). At the stage of mild dementia clearly identified the most features of amnestic aphasia, amnestic disorder component of praxis, and in some cases, signs of constructive dyspraxia. There is a long preservation of motor component of praxis. The total scores on the MMSE and the GDR is a sensitive indicator of cognitive deficits and higher cortical functions of mild to moderate AD before, is effective in determining therapeutic approaches and tactics of early prevention in patients with AD.