Biological resistance to beta-lactamic antibiotics in patients with respiratory infection in the prediction of efficiency of antibacterial therapy
Annotatsiya
<b>Purpose:</b> To assess the level of formation of biological resistance to beta-lactam antibiotics in the prediction of the effectiveness of antibiotic therapy. <b>Material and Methods:</b> The level of beta-lactamase activity (BLA) of biological fluids in 52 patients with exacerbated respiratory infection was assessed by the test system "BioLactam" (Belarus). <b>Results:</b> The average level of BLA in the blood serum of healthy people was 55.4%, and bronchial secretion - 31.5%. It was noted that in individuals with a body temperature of more than 380 BLA serum was significantly higher, accounting for 70.3%. In patients with profound manifestations of metabolic acidosis, the level of blood BLA was 8.4%, and in cases of respiratory uncompensated alkalosis, it reached 75.7%. Analysis of the blood BLA level in patients with antibacterial therapy with first-line beta-lactams for more than 45 days and changing them more than 4 times a year showed that in 68% of these patients the blood BLA level was often high up to 68.1%. The established level of BLA sputum is more than 40% and blood more than 68.5% requires the elimination of first-line beta-lactam drugs and the prescription of antibiotics for the reserve, in particular, inhibitor-protected beta-lactams, carbapenems, or drugs from other pharmacological groups. <b>Conclusion:</b> Assessing the level of BLA in biological secrets will allow up to 30% reduce the unreasonable use of beta-lactam antibiotics and contribute to overcoming the risks of formation of antibiotic resistance.