Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women
Valgerður SteinthórsdóttirdeCODE genetics/Amgen Inc., Reykjavik, Iceland. [email protected]Ralph McGinnisWellcome Sanger Institute, Cambridge, UK. [email protected]Nicholas WilliamsWellcome Sanger Institute, Cambridge, UKLilja StefánsdóttirdeCODE genetics/Amgen Inc., Reykjavik, IcelandGuðmar ÞorleifssondeCODE genetics/Amgen Inc., Reykjavik, IcelandScott ShooterWellcome Sanger Institute, Cambridge, UKJoão FadistaDepartment of Clinical Sciences, Lund University Diabetes Centre, Malmö, SwedenJon K. SigurdssondeCODE genetics/Amgen Inc., Reykjavik, IcelandKirsi AuroFinnish Institute for Health and Welfare, Helsinki, FinlandGalina BerezinaScientific Center of Obstetrics, Gynecology and Perinatology, Almaty, KazakhstanMaria Carolina BorgesMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UKSuzannah BumpsteadWellcome Sanger Institute, Cambridge, UKJonas Bybjerg‐GrauholmDepartment for Congenital Disorders, Danish Centre for Neonatal Screening, Statens Serum Institut, Copenhagen, DenmarkIrina ColgiuWellcome Sanger Institute, Cambridge, UKVivien A. DolbyLeeds Institute of Medical Research (LIMR), School of Medicine, University of Leeds, Leeds, UKFrank DudbridgeDepartment of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UKStephanie M. EngelDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAChristopher FranklinWellcome Sanger Institute, Cambridge, UKMichael L. FriggedeCODE genetics/Amgen Inc., Reykjavik, IcelandYr FrisbækDepartment of Obstetrics and Gynecology, Landspitali University Hospital, Reykjavik, IcelandReynir Tómas GeirssonDepartment of Obstetrics and Gynecology, Landspitali University Hospital, Reykjavik, IcelandFrank GellerDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, DenmarkSólveig GrétarsdóttirdeCODE genetics/Amgen Inc., Reykjavik, IcelandDaníel F. GuðbjartssonSchool of Engineering and Natural Sciences, University of Iceland, Reykjavik, IcelandQuaker E. HarmonEpidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC, USADavid M. HougaardDepartment for Congenital Disorders, Danish Centre for Neonatal Screening, Statens Serum Institut, Copenhagen, DenmarkTatyana HegayInstitute of immunology and human genomics, Uzbek Academy of Sciences, Tashkent, UzbekistanAnna HelgadóttirdeCODE genetics/Amgen Inc., Reykjavik, IcelandSigrun HjartardottirDepartment of Obstetrics and Gynecology, Landspitali University Hospital, Reykjavik, IcelandTiina JääskeläinenMedical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, FinlandHrefna JohannsdottirdeCODE genetics/Amgen Inc., Reykjavik, IcelandIngileif JónsdóttirFaculty of Medicine, University of Iceland, Reykjavik, IcelandThorhildur JuliusdottirdeCODE genetics/Amgen Inc., Reykjavik, IcelandNoor KalshekerSchool of Life Sciences, University of Nottingham, Nottingham, UKA. K. KasimovInstitute of immunology and human genomics, Uzbek Academy of Sciences, Tashkent, UzbekistanJohn P. KempMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UKKatja KivinenDivision of Cardiovascular Medicine, University of Cambridge, Cambridge, UKKari KlungsøyrDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, NorwayWai LeeInstitute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UKMads MelbyeDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, DenmarkZosia MiedzybrodskaDivision of Applied Medicine, School of Medicine, Medical Sciences, Nutrition and Dentistry, University of Aberdeen, Aberdeen, UKAshley MoffettDepartment of Pathology, University of Cambridge, Cambridge, UKDilbar NajmutdinovaRepublic Specialized Scientific Practical Medical Centre of Obstetrics and Gynecology, Tashkent, UzbekistanFiruza NishanovaRepublic Specialized Scientific Practical Medical Centre of Obstetrics and Gynecology, Tashkent, UzbekistanThorunn A. OlafsdottirFaculty of Medicine, University of Iceland, Reykjavik, IcelandMarkus PerolaFinnish Institute for Health and Welfare, Helsinki, FinlandFiona Broughton PipkinSchool of Medicine, University of Nottingham, Nottingham, UKLucilla PostonDepartment of Women and Children's Health, King's College London, London, UKGordon PrescottDivision of Applied Medicine, School of Medicine, Medical Sciences, Nutrition and Dentistry, University of Aberdeen, Aberdeen, UKSaedís SaevarsdóttirdeCODE genetics/Amgen Inc., Reykjavik, IcelandDamilya SalimbayevaScientific Center of Obstetrics, Gynecology and Perinatology, Almaty, KazakhstanPaula J. ScaifeSchool of Medicine, University of Nottingham, Nottingham, UKLine SkotteDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, DenmarkEleonora Staines-UriasDepartment of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UKÓlafur Andri StefánssondeCODE genetics/Amgen Inc., Reykjavik, IcelandKarina Meden SørensenThe Danish National Biobank, Statens Serum Institut, Copenhagen, DanmarkLiv Cecilie Vestrheim ThomsenDepartment of Clinical Science, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayVinicius TraganteDivision Heart & Lungs, Department of Cardiology, University Medical Center Utrecht, University of Utrecht, Utrecht, The NetherlandsLill TrogstadDepartment of Infectious Disease Epidemiology and Modelling, Norwegian Institute of Public Health, Oslo, NorwayNigel SimpsonDivision of Womens and Children's Health, School of Medicine, University of Leeds, Leeds, UKHannele LaivuoriDepartment of Obstetrics and Gynecology, Tampere University Hospital and Tampere University, Faculty of Medicine and Health Technology, Tampere, FinlandSeppo HeinonenObstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, FinlandEero KajantieDepartment of Clinical and Molecular Medicine, Norwegian University of Health and Technology, Trondheim, NorwayJuha KereSchool of Basic & Medical Biosciences, King's College London, London, UKAnneli PoutaDepartment of Government Services, National Institute for Health and Welfare, Helsinki, FinlandLinda MorganSchool of Life Sciences, University of Nottingham, Nottingham, UKJames J. WalkerLeeds Institute of Medical Research (LIMR), School of Medicine, University of Leeds, Leeds, UKSheila MacphailNewcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UKMark D. KilbyThe Centre for Women's & Newborn Health, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UKMarwan HabibaUniversity of Leicester, Leicester, UKCatherine WilliamsonDivision of Women's Health, Kings College London, London, UKKevin M. O’ShaughnessyDepartment of Medicine, University of Cambridge, Cambridge, UKShaughn O’BrienKeele University School of Medicine, Stoke-on-Trent, UKAlan C. CameronInstitute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UKChristopher W.G. RedmanNuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, UKMartin FarrallRadcliffe Department of Medicine, University of Oxford, Oxford, UKMark J. CaulfieldWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, UKAnna F. DominiczakInstitute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UKTamara AripovaInstitute of immunology and human genomics, Uzbek Academy of Sciences, Tashkent, UzbekistanJuan P. CasasDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USAUnnur ÞorsteinsdóttirFaculty of Medicine, University of Iceland, Reykjavik, IcelandAnn‐Charlotte IversenDepartment of Clinical and Molecular Medicine, Centre of Molecular Inflammation Research (CEMIR), Norwegian University of Science and Technology (NTNU), Trondheim, NorwayBjarke FeenstraDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, DenmarkDebbie A. LawlorBristol NIHR Biomedical Research Centre, Bristol, UKHeather A. BoydDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, DenmarkPer MagnusCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, NorwayNodira ZakhidovaInstitute of immunology and human genomics, Uzbek Academy of Sciences, Tashkent, UzbekistanGulnara SvyatovaScientific Center of Obstetrics, Gynecology and Perinatology, Almaty, KazakhstanKāri StefánssonFaculty of Medicine, University of Iceland, Reykjavik, Iceland
ABI
Annotatsiya
Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.
Hali tarjima qilinmagan
Mavzular
Identifikatorlar
Iqtiboslar va manbalar
0 ta iqtibos79 ta foydalanilgan manba