PHARMACOKINETICS OF ANTIBIOTICS IN EXPERIMENTAL GUNSHOT WOUNDS
Gulomidin Minkhodzhievich HodjimatovProfessor of the Department of General Surgery of the Faculty of Professional Development and Training of Doctors of Andijan State Medical InstituteKamal Karimovich MirzaevAssociate professor of the Department of General Surgery of the Faculty of Professional Development and Registration of Doctors of Andijan State Medical InstituteDilshod Turdaliyevich AzizovAssistant Professor, Department of General Surgery, Andijan State Medical Institute
ABI
Annotatsiya
Experimental studies on the pharmacokinetics of gentamicin were performed on 40 rabbits with various methods of injection after the infliction of gunshot wounds on extremities. The results showed that the method of lymphotropic antibiotic therapy provides a more stable and long-term saturation of blood. The highest and the longest retaining concentration of gentamicin in the lymph nodes and soft tissue of gunshot wounds is reached at lymphotropic method of injection.
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