Maqola

Molecular and crystal structure of a copper(II) complex of sildenafil

Akhmatkhodja N. YunuskhodjayevShokhista F. IskandarovaTashkent Pharmaceutical Institute , Aybek Str., 45 , 100015 , Tashkent , UzbekistanVahobjon Kh. SabirovInnovation Center of Pharmacy , 46 Building, 19 Quarter , Yunusabad District , 100114 , Tashkent , Uzbekistan

Zeitschrift für Naturforschung Bjournal2021en

ABI

Annotatsiya

Abstract The crystal structure of a copper(II) complex of protonated sildenafil, CuCl 3 C 22 H 31 N 6 O 4 S⋅2H 2 O was studied by single crystal X-ray diffraction. The compound crystallizes in the monoclinic space group P 2 1 / n with the unit cell parameters a = 15.4292(2), b = 9.06735(12), c = 21.1752(2) Å, V = 2945.48(7) Å 3 , Z = 4. The Cu atom is coordinated by the sildenafil ligand via the N2 atom of the pyrazolopyrimidine ring and by three chloride anions. Sildenafil is protonated at the methylated N6 atom of the piperazine ring and it is cation ligand with a 1+ charge.

Mavzular

Phenothiazines and Benzothiazines Synthesis and Activities Crystal structures of chemical compounds Synthesis and Catalytic Reactions

Identifikatorlar

DOI: 10.1515/znb-2021-0145

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