Evaluation of Anticonvulsant Activity of Allapinine and N-Deacetylappaconitine in Experimental Animals.
Zafar Isomiddinovich SanoevAcademy of Sciences RUz Institute of Chemistry of Plant Substances, Tashkent, UzbekistanTolmas Tolibovich KhamroevAcademy of Sciences RUz Institute of Chemistry of Plant Substances, Tashkent, UzbekistanIbrokhim Tuychievich AbdinazarovAcademy of Sciences RUz Institute of Chemistry of Plant Substances, Tashkent, UzbekistanSokhib Zamon ugli RashidovAcademy of Sciences RUz Institute of Chemistry of Plant Substances, Tashkent, UzbekistanSukhrob Davlatyor ugli RakhimboevAcademy of Sciences RUz Institute of Chemistry of Plant Substances, Tashkent, Uzbekistan
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The present article presents a research paper on the evaluation of anticonvulsant activity of allapinine and N-debacetylappaconitine with high antiarrhythmic activity caused at different doses and with different analyzers. The results of the conducted studies showed that allapinine and N-debacetylappaconitine are not inferior and even slightly superior to carbamazepine in anticonvulsant activity. In this regard, based on the conducted studies, it can be concluded that allapinin affects not only cardiomyocytes, but also ion exchange in nerve cells.
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