PARAMETERS OF CHANGING COAGULATION SYSTEM IN PREGNANT WOMEN WITH PREECLAMPSIA

Objective: The reasons for the development of preeclampsia are multifactorial, complex and not fully understood. However, according to modern concepts, the leading role belongs to endothelial damage, changes in platelet function, as well as immunological and genetic factors. Purpose of our study: to investigate changes of hemostasiological indicators in women with preeclampsia. Design and method: We conducted a study of the blood coagulation system in 68 pregnant women in the third trimester, of which 34 were pregnant with a physiological course of the gestational period (control group) and 38 pregnant women with preeclampsia (main group). The age of the women surveyed ranged from 20 to 42 years. The average age of women in the main group was 28.13 ± 0.83, and in the control group, 29.27 ± 0.70 years. Results: A significant decrease in the average platelet count in women with severe preeclampsia relative to healthy pregnant women in the third trimester of pregnancy (161.2 ± 9.6 × 109 / l and 193.5 ± 8.7 × 109 / l) (P < 0.05) When studying platelet aggregation activity, we found that platelet aggregation activity was significantly higher in the main group –112.7 ± 3.5 compared with the control group — 99.8 ± 3.3 (P < 0.05). The concentration of fibrinogen, the main substrate of blood coagulation, was slightly higher in pregnant women with preeclampsia - 4.0 ± 0.2 g / l than in women with physiological pregnancy - 3.5 ± 0.17 g / l. In pregnant women with preeclampsia in the III trimester, a statistically significant shortening of ABP was established - 43.9 ± 0.9 seconds compared with the control - 51.2 ± 0.2 seconds (P < 0.001). Conclusions: Women with preeclampsia have signs of a subacute form of disseminated intravascular coagulation and signs of thrombocytopathy and consumption coagulopathy in combination with a decrease in blood anticoagulant and fibrinolytic potential.

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