Inherited thrombophilia in the development of thrombotic conditions in patients with COPD

<b>Background:</b> The many studies have established that the leading cause of death in patients with chronical obstructive pulmonary disease (COPD) is not chronic heart or respiratory failure, as is traditionally believed, but cardiovascular events of thrombotic genesis. Inasmuch as the inherited thrombophilia single nucleotide polymorphisms (SNPs) factor V G1691A (FV-Leiden) and prothrombin (PRT) G20210A are inherited risk factors of thrombotic events. The aim of this study was to determine the frequency and prevalence of single and combined SNPs in 125 patients with documented COPD, divided into&nbsp;groups depending on the presence of thrombotic events in the anamnesis. <b>Material and methods:</b> Factor V-Leiden, PRT G20210A were analyzed by PCR and restriction fragment length polymorphism (RFLP) in two groups patients with documented COPD (the first group – 75 patients with COPD without thrombosis; second group – 50 patients with COPD and thrombotic events in anamnesis). <b>Results:</b> The frequency of occurrence of G allele of the G1691A (FV-Leiden) gene in the first group was 99.3%, in the second group – 97.0% and A allele in the first group was 0.7%, in the second group – 4.0%. The prevalence of the heterozygote variants for FV-Leiden estimated in group with thrombosis (8.02 vs. 1.33%, RR 6.0), PRT G20210A (6.2 vs. 1.33%; RR 6.38). Homozygous variants for FV-Leiden and for PRT G20210A – A/A genotype is not detected in both group. <b>Conclusions:</b> The frequency of occurrence of the heterozygous genotype G / A for FV-Leiden and PRT G20210A in the COPD patients with thrombotic events significantly exceeded the frequency in the group COPD patients with out trombosis, which may indicate the role of this genes in the development of thrombophilic conditions in COPD.

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