Association of the tgf-β1 gene with the development of varicose disease and its thrombotic complications

Abstract:This article presents the results of a study of the role of rs1800471 polymorphism of introns of the transforming growth factor beta-1 (TGF-β1) gene in the development of varicose vein disease and its complications.  The purpose of the study was to determine the role of the rs1800471 polymorphism of the TGF-β1 gene in the development of varicose vein disease of the lower extremities (VVLE) and VVLE complicated by thrombosis. Materials & Methods. The frequency of TGF-β1 gene polymorphism rs1800471 detection by Real-Time PCR was studied in the blood of 161 patients of the main group, including 111 patients with VVLE and 55 patients with VVLE complicated by thrombosis in comparison with the group of 155 healthy subjects. Results. Heterozygous G/C genotype was significantly more frequently revealed among patients with venous thrombosis than in the control group, which increased the risk of disease development almost fourfold in the group of patients with venous thrombosis (χ2>3.84; p<0.05; OR=3.9; 95%CI:1.64-8.98) (р<0.05). Conclusions. The presence of heterozygous G/C genotype of TGF-β1 gene has diagnostic and prognostic significance and increases the risk of VVLE complicated by venous thrombosis.

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