DEVELOPMENT OF A METHOD FOR QUANTITATIVE DETERMINATION OF DEXPANTHENOL IN 5% GEL DOSAGE FORM AND ITS VALIDATION.
Khamdamov M.M.Tashkent Pharmaceutical InstituteDusmatov A.F.,Tashkent Pharmaceutical InstituteRizayev K.STashkent Pharmaceutical InstituteChulpanov K.ATashkent Pharmaceutical InstituteKarieva Y.S.Tashkent Pharmaceutical InstituteKhadjmetova S.R.Tashkent Pharmaceutical Institute
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Abstract. This article presents the results of a study on the development and validation of a high performance liquid chromatography technique for the quantitative determination of dexpanthenol in 5% anti-inflammatory gels. On the basis of the validation, the criteria for the acceptability of the method were established and it was proved that the proposed method for the quantitative determination of dexpanthenol is specific, linear in the range of its application, correct and precise.\n\n\nThe developed validated method for the quantitative determination of dexpanthenol was proposed for inclusion in the draft pharmacopoeial monograph of the manufacturer.
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