MECHANISM OF DEVELOPMENT AND DIAGNOSTIC MARKERS OF NEPHROPATHY IN ARTERIAL HYPERTENSION

Abstract. Hypertension is an epidemic in our society and is the most common cardiovascular disease. So, many studies have shown a link between the severity and duration of hypertension and the frequency of development of CKD. At the same time, joining CKD leads to poor level control blood pressure (BP) and patient prognosis of arterial hypertension. Therefore, early detection of kidney damage is an urgent problem, the solution of which is complicated by the asymptomatic course of the initial stages of kidney damage, which essentially makes timely diagnosis difficult. Microalbuminuria (MAU) is a marker of kidney damage and the risk of cardiovascular complications. Increasing MAU has now acquired the value of an integral marker of poor prognosis since it reflects a generalized dysfunction of the endothelium, which causes damage to target organs (myocardium, vascular wall, kidney) and is observed even with a slight increase in urinary albumin excretion (“low-value albuminuria”).

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