Iron Deficiency Anemia Caused by Chronic Kidney Disease Complicated by Chronic Heart Failure, Treatment, Improvement of Prognosis

Abstract: In the presented review, the prevalence of anemia and iron deficiency (railway) with CXN, their influence on the course of the course and forecast of this state are affected. The definition of anemia and a railway is formulated based on the assessment of various laboratory data. In particular, the diagnostic significance of the determination of serum iron, serum ferritin, transferin saturation coefficient, a common iron-binding ability of blood serum and transferlic soluble receptor levels are discussed. It is emphasized by the importance of determining the level of iron in the bone marrow, although being the "gold standard" diagnosis of railway, but rarely used in wide clinical practice. Pathogenetic mechanisms for the development of the CHD for CHD, including the lack of iron intake, the role of inflammation, erythropoietin, RAAS, and the influence of some pharmacological preparations. The physiological consequences of the railway and anemia are described, the activation of hemodynamic and non-aggative compensatory mechanisms developing in response to anemia and often exacerbating CXN. Particular attention is paid to modern approaches in the treatment of anemia and railway with HSN, including discussion of the effectiveness and safety of oral, intravenously administered iron and hematopoiesis stimulants. Keywords: anemia, iron deficiency, chronic heart failure, Diagnostics, Erythropoietin, Ferritin, Transfirin, Hepsidine, Pathogenesis, Forecast, Treatment

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