The effect of D-115 oxadiazole and D-378 triazole on the contractile activity of rat aortic smooth muscle segments
Mirzaeva Yu.T.1Institute of Biophysics and Biochemistry at the National University of Uzbekistan, Tashkent, UzbekistanIsmailova D.S.2Institute of Chemistry of Plant Substances, acad. S.Yu.Yunusov AS RUz, Tashkent, UzbekistanUsmanov P.B.1Institute of Biophysics and Biochemistry at the National University of Uzbekistan, Tashkent, UzbekistanRejabboeva N. L.
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Abstract. A mechanographic study of the contractile activity of rat aortic smooth muscle cells is presented to investigate the action of 4-Amino-5-(2-aminophenyl)-2,4-dihydro-3H-1,2,4-triazolo-3-thione (D-378). Vasorelaxant effects have been demonstrated for D-115 oxadiazole and D-378 triazole. Simultaneously, it was discovered that D-378 triazole obtained by synthesis on the basis of D-115 oxadiazole with hydrosine hydrate has pronounced vasorelaxant activity. In this regard, we conducted comparative studies of the effect of D-115 oxadiazole and D-378 triazole on the contractile activity of SMCs in the rat aorta to determine the dependence of the relaxant activity of D-378 triazole on its structure.
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