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Regulation of Transport of Ca2+ NMDA-Receptors in Rat Brain Synaptosomes Under the Influence of Polyphenols

Alisher A. MukhtorovNamangan State University, Namangan, UzbekistanRahmatjon R. MamadaminovNamangan State University, Namangan, UzbekistanNozim N. КhoshimovInstitute of Biophysics and Biochemistry at the National University of Uzbekistan, Tashkent, UzbekistanKabil E. NasirovInstitute of Biophysics and Biochemistry at the National University of Uzbekistan, Tashkent, UzbekistanR. N. RakhimovLutpillaev Gaybullo; BezprozvannyI -BezprozvannyDuchenM 1999 -DuchenFanGrynkiewizHandleyJungKarchKhachaturianZ 1987 -KhachaturianKhoshimovKhshimvMiyashitaChan NdountseL -NdountseH ChanPankratovPetersonRakhimov; RothsteinJ -RothsteinTiraboschiWeilerWenZhang

European Journal of Medicinejournal2022en

ABI

Annotatsiya

It is known that disturbance of Ca 2+ dynamics in nerve cells is universally involved in all pathologies of Alzheimer's disease (AD). It is likely that the use of chemical agents or small molecules specific for Ca 2+ channels or membranes of intracellular organelles to correct Ca 2+ dysregulation of neurons may open up a new approach to the prevention and treatment of AD. The experiments were carried out according to the Weiler method. Synaptosomes were isolated from the brain of rats by two-stage centrifugation at a temperature of 4C.To measure the amount of cytosolic Ca 2+ synaptosomes were calculated by the Grinkevich equation. The results of the experiments show that there is a possibility of competition between different polyphenols of Caralinia, Granatuum and glutamate for the site of regulation of the opening ion channels f NMDA-receptors.

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Mavzular

Neuroscience and Neuropharmacology Research Biochemical Analysis and Sensing Techniques Ziziphus Jujuba Studies and Applications

Identifikatorlar

DOI: 10.13187/ejm.2022.1.3

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