CLINICAL MANIFESTATIONS, IMMUNOPATOGENESIS OF DIFFUSE TOXIC GOITER

This review of the literature is devoted to an actual problem in the field of endicrinology, such as DTG. The main clinical manifestations of DTG associated with an excess of thyroid hormones, affecting simultaneously several different body systems, are shown. The role of immunological mechanisms, interleukins in the formation of the disease is described. Damage to the cardiovascular system is a frequent and serious complication of diffuse toxic goiter (DTG), which often comes to the fore in the clinical picture and determines the course and outcome of the disease. To designate this lesion, R. Kraus in 1899 introduced the term “thyrotoxic heart”, and at present it is understood as a symptom complex of disorders of the cardiovascular system caused by the toxic effect of excess thyroid hormones (TE) and characterized by the development of hyperfunction, hypertrophy, dystrophy , cardiosclerosis and heart failure (HF).

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