PATHOGENESIS OF ULCEROGENESIS IN THE STOMACH AND DUODENUM

<em>As is known, the formation and formation of the immune system is a process that is determined by the interaction of the gene regulation of development with environmental factors (antigens). Peptic ulcer of the stomach and duodenum is a chronic recurrent disease that occurs with alternating periods of exacerbation and remission, the main morphological feature of which is the formation of ulcers in the stomach and / or duodenum. The ulcerative defect penetrates through the muscle plate of the mucous membrane into the submucosal base or deeper. Under normal conditions, aggressive and protective factors are balanced, and therefore damage to stomach cells does not occur, however, in case of violation of this balance, damage to the mucosa in the form of erosions and / or ulcers may occur. Protective factors are represented by three components: preepithelial, epithelial, and postepithelial. The preepithelial mucus includes mucin, bicarbonates and surfactant phospholipids. The epithelial component includes surface cells, their apical dense contacts and membrane transporters.</em>

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