MARKERS OF ENDOTHELIAL DYSFUNCTION IN DISTAL VESSELS OF PATIENTS WITH CHRONIC PAIN SYNDROME WITH DORSOPATHIES OF VARIOUS GENESIS

For our scientific work, the presence of endothelin-1 was studied using a three-phase enzyme immunoassay in the peripheral blood serum of patients with chronic pain syndrome in dorsopathies of various origins. Dorsopathy is a common pathology accompanied by aseptic inflammation in the spine, but has not been studied for markers of inflammation. The study of indicators and comparative correlation of markers of inflammatory metamorphism in the peripheral blood of patients with chronic pain syndrome in dorsopathies of various origins was carried out. 320 patients with chronic pain syndrome with dorsopathies of various origins, who are being treated in the neurology department of the City Medical Association of Samarkand in the period from 2018 to 2021, were selected. The research methods used blood tests for the presence of endothelin-1. According to the results of the study, obtained in the study of patients with dorsopathies of compression-ischemic genesis, brucellosis, rheumatic and herpetic genesis, showed that the concentration of endothelin-1 in the blood serum of the studied patients was increased several times, and can be selected as an additional biochemical criterion for differential diagnosis of patients with chronic pain syndrome in dorsopathies of various origins. Thus, in patients with chronic pain syndrome with dorsopathies of compression-ischemic genesis, brucellosis, rheumatic and herpetic genesis, the detected concentrations of endothelin-1 in the blood serum indicated endothelial lesions in peripheral vessels, provoking chronic pain, indicating an inflammatory nature, determining the chronic course and the nature of the pain.

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