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What is the influence of grape products on liver enzymes? A systematic review and meta‐analysis of randomized controlled trials

Sadia GhaffarMehak Ali NaqviDental Section, Punjab Medical College, Faisalabad, PakistanAddeela FayyazFatima Jinnah Medical University, Lahore, PakistanMohammed Kadhem AbidDepartment of Anesthesia, College of Health & Medical Technology, Al-Ayen University, Thi-Qar, IraqKakhramon Najmiddinovich KhayitovTashkent Pediatric Medical Institute, Bogishamol Street 223, Tashkent, UzbekistanAbduladheem Turki JalilMedical Laboratories Techniques Department, Al-Mustaqbal University College, Babylon, Hilla 51001, IraqFahad AlsaikhanDepartment of Clinical Pharmacy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Kingdom of Saudi ArabiaAli Thaeer HammidComputer Engineering Techniques Department, Faculty of Information Technology, Imam Ja'afar Al-Sadiq University, Baghdad, IraqMoaed E. Al‐GazallyCollege of Medicine, University of Al-Ameed, Karbala, IraqVida MohammadparastSchool of Health Sciences, Massey University, Wellington, New ZealandBehrooz JannatHalal Research Center of IRI, Food and Drug Administration, Ministry of Health and Medical Education, Tehran, IranMehran NouriDepartment of Community Nutrition, School of Nutrition and Food Science, Shiraz University of Medical Sciences, Shiraz, Iran; Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: [email protected]

Complementary Therapies in Medicinejournal2022en

ABI

Annotatsiya

This systematic review and meta-analysis were aimed to determine the effects of grape products on liver enzymes in adults. Databases including PubMed/Medline, Cochrane Library, ISI Web of Science, and Scopus were searched up to February 2021. Randomized clinical trials (RCTs) investigating the effect of grape products on serum concentrations of liver enzymes were included. Data were pooled using the random-effects model and weighted mean difference (WMD) was considered as the summary effect size. Eight RCTs enrolling 291 participants met the inclusion criteria for this meta-analysis. The overall effect illustrated no significant change in serum levels of alanine aminotransferase (ALT) (WMD: − 2.04; 95 % CI: − 5.50 to 1.42; P = 0.24; I2 = 72.5 %), and aspartate aminotransferase (AST) (WMD: − 1.40; 95 % CI: − 3.80 to 0.99; P = 0.25; I2 = 76.0 %) in intervention group compared with the control group. Subgroup analyses revealed that the effect of grape products on ALT (WMD: − 4.97; 95 % CI: − 8.73 to − 1.21; P = 0.01) and AST (WMD: − 2.89; 95 % CI: − 5.69 to − 0.08; P = 0.04) levels was significant when the intervention period was equal or more than 12 weeks. Overall, grape products had no signiﬁcant effect on liver enzymes in adults. However, due to the low number of included studies, these findings must be interpreted with great caution. Larger, well-designed RCTs are still needed to further evaluate the capacity of the grape products as a complementary treatment to improve liver enzymes.

Hali tarjima qilinmagan

Mavzular

Liver Disease Diagnosis and Treatment Drug-Induced Hepatotoxicity and Protection Phytochemicals and Antioxidant Activities

Identifikatorlar

DOI: 10.1016/j.ctim.2022.102845

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