Core–shell structured microneedles with programmed drug release functions for prolonged hyperuricemia management
Rui WangInternational Scientific and Technological Cooperation Base of Intelligent Biomaterials and Functional Fibers of Zhejiang Province, Hangzhou, 310018, ChinaYanfang SunCollege of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, Zhejiang, 310018, ChinaHan WangWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, ChinaTianqi LiuInternational Scientific and Technological Cooperation Base of Intelligent Biomaterials and Functional Fibers of Zhejiang Province, Hangzhou, 310018, ChinaAmin ShavandiBioMatter unit-École polytechnique de Bruxelles, Université Libre de Bruxelles, Brussels, BelgiumLei NieCollege of Life Science, Xinyang Normal University, Xinyang 464000, ChinaKhaydar E. YunusovInstitute of Polymer Chemistry and Physics, Uzbekistan Academy of Sciences, Tashkent, 100128, UzbekistanGuohua JiangInternational Scientific and Technological Cooperation Base of Intelligent Biomaterials and Functional Fibers of Zhejiang Province, Hangzhou, 310018, China
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results showed that the as-fabricated MNs exhibited an excellent anti-hyperuricemia effect to reduce SUA levels to the normal state within 3 h and maintain the normouricemia state for 12 h. In addition, the levels of creatinine (Cr) and blood urea nitrogen (BUN) in the serum remained within the normal range, and the activities of adenosine deaminase (ADA) and xanthine oxidase (XOD) in the liver were effectively inhabited, mitigating the risk of liver and kidney damage for clinical anti-hyperuricemia management.
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