Maqola

Laboratory and free-living gait performance in adults with COPD and healthy controls

Joren BuekersCIBER Epidemiología y Salud Pública, Barcelona, SpainDimitrios MegaritisDepartment of Sport, Exercise and Rehabilitation, Northumbria University Newcastle, Newcastle upon Tyne, UKSarah KochCIBER Epidemiología y Salud Pública, Barcelona, SpainLisa AlcockNational Institute for Health and Care Research Newcastle Biomedical Research Centre, Newcastle University and The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UKNadir AmmourClinical Science and Operations, GlobalDevelopment, Sanofi R&D, Chilly-Mazarin, FranceClemens BeckerRobert Bosch Gesellschaft für Medizinische Forschung, Stuttgart, GermanyStefano BertulettiDepartment of Biomedical Sciences, University of Sassari, Sassari, ItalyTecla BonciDepartment of Mechanical Engineering and INSIGNEO Institute for In Silico Medicine, The University of Sheffield, Sheffield, UKPhilip M. BrownThe Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UKEllen BuckleyDepartment of Mechanical Engineering and INSIGNEO Institute for In Silico Medicine, The University of Sheffield, Sheffield, UKSara ButteryNational Lung and Heart Institute, Imperial College, London, UKBrian CaulfiedInsight Centre for Data Analytics, University College Dublin, Dublin, IrelandAndrea CereattiPolytechnic University of Torino, Department of Electronics and Telecommunications, Turin, ItalyNikolaos ChynkiamisDepartment of Sport, Exercise and Rehabilitation, Northumbria University Newcastle, Newcastle upon Tyne, UKHeleen DemeyerDepartment of Rehabilitation Sciences, Ghent University, Ghent, BelgiumCarlos EchevarriaThe Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UKAnja FreiEpidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, SwitzerlandClint HansenDepartment of Neurology, University Hospital Schleswig-Holstein and Kiel University, Kiel, GermanyJeffrey M. HausdorffCenter for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, IsraelNicholas S HopkinsonNational Lung and Heart Institute, Imperial College, London, UKEmily HumeDepartment of Sport, Exercise and Rehabilitation, Northumbria University Newcastle, Newcastle upon Tyne, UKArne KuederleMachine Learning and Data Analytics Lab, Department of Artificial Intelligence in Biomedical Engineering, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, GermanyWalter MaetzlerDepartment of Neurology, University Hospital Schleswig-Holstein and Kiel University, Kiel, GermanyClaudia MazzàDepartment of Mechanical Engineering and INSIGNEO Institute for In Silico Medicine, The University of Sheffield, Sheffield, UKEncarna M. Micò-AmigoTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UKArne MuellerNovartis Institutes for Biomedical Research, Basel, SwitzerlandLuca PalmeriniDepartment of Electrical, Electronic and Information Engineering "Guglielmo Marconi", University of Bologna, Bologna, ItalyFrancesca SalisDepartment of Biomedical Sciences, University of Sassari, Sassari, ItalyKirsty ScottDepartment of Mechanical Engineering and INSIGNEO Institute for In Silico Medicine, The University of Sheffield, Sheffield, UKThierry TroostersKU Leuven, Department of Rehabilitation Sciences and Pulmonary Rehabilitation, Respiratory Division, University Hospital Gasthuisberg, Leuven, BelgiumBeatrix VereijkenDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, NorwayHenrik WatzPulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung Research (DZL), Grosshansdorf, GermanyLynn RochesterNational Institute for Health and Care Research Newcastle Biomedical Research Centre, Newcastle University and The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UKSilvia Del DinNational Institute for Health and Care Research Newcastle Biomedical Research Centre, Newcastle University and The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UKIoannis VogiatzisDepartment of Sport, Exercise and Rehabilitation, Northumbria University Newcastle, Newcastle upon Tyne, UKJudith García‐AymerichCIBER Epidemiología y Salud Pública, Barcelona, Spain

ERJ Open Researchjournal2023en

ABI

Annotatsiya

Background: Gait characteristics are important risk factors for falls, hospitalisations and mortality in older adults, but the impact of COPD on gait performance remains unclear. We aimed to identify differences in gait characteristics between adults with COPD and healthy age-matched controls during 1) laboratory tests that included complex movements and obstacles, 2) simulated daily-life activities (supervised) and 3) free-living daily-life activities (unsupervised). Methods: This case-control study used a multi-sensor wearable system (INDIP) to obtain seven gait characteristics for each walking bout performed by adults with mild-to-severe COPD (n=17; forced expiratory volume in 1 s 57±19% predicted) and controls (n=20) during laboratory tests, and during simulated and free-living daily-life activities. Gait characteristics were compared between adults with COPD and healthy controls for all walking bouts combined, and for shorter (≤30 s) and longer (>30 s) walking bouts separately. Results: , 95% CI: -12.3 to -0.9) were recorded in adults with COPD compared to healthy controls during longer (>30 s) free-living walking bouts, but not during shorter (≤30 s) walking bouts in either laboratory or free-living settings. Double support duration and gait variability measures were generally comparable between the two groups. Conclusion: Gait impairment of adults with mild-to-severe COPD mainly manifests during relatively long walking bouts (>30 s) in free-living conditions. Future research should determine the underlying mechanism(s) of this impairment to facilitate the development of interventions that can improve free-living gait performance in adults with COPD.

Mavzular

Chronic Obstructive Pulmonary Disease (COPD) Research Balance, Gait, and Falls Prevention Cardiovascular and exercise physiology

Identifikatorlar

DOI: 10.1183/23120541.00159-2023

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