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Radiomic Phenotype of Periatrial Adipose Tissue in the Prognosis of Late Postablation Recurrence of Idiopathic Atrial Fibrillation

J.N. IlyushenkovaSenior Researcher, Nuclear Medicine Department; Cardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 111a Kievskaya St., Tomsk, 634012, RussiaS.I. SazonovaHead of Nuclear Medicine Department; Cardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 111a Kievskaya St., Tomsk, 634012, RussiaE.V. PopovPhD Student, Nuclear Medicine Department; Cardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 111a Kievskaya St., Tomsk, 634012, RussiaР. Е. БаталовLeading Researcher, Department of Surgical Treatment of Advanced Heart Rhythm Disorders and Pacing; Cardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 111a Kievskaya St., Tomsk, 634012, RussiaS.M. MininHead of the Nuclear Diagnosis Unit, Department of Radiological and Functional Diagnosis; Meshalkin National Medical Research Center of the Ministry of Health of the Russian Federation, 15 Rechkunovskaya St., 630055, Novosibirsk, RussiaA.B. RomanovDeputy Director for Science; Meshalkin National Medical Research Center of the Ministry of Health of the Russian Federation, 15 Rechkunovskaya St., 630055, Novosibirsk, Russia
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is to find new predictors of postablation atrial fibrillation (AF) recurrence in patients with lone AF using a texture analysis of the periatrial adipose tissue (PAAT) of the left atrium. Materials and Methods: Forty-three patients admitted for lone AF catheter ablation, who had undergone multispiral coronary angiography, were enrolled in the study. PAAT segmentation was performed using 3D Slicer application followed by extraction of 93 radiomic features. At the end of the follow-up period, patients were divided into 2 groups depending on the presence or absence of AF recurrence. Results: =0.451, OR - 0.506, 95% CI: 0.331‒0.776, p<0.001). Conclusion: The radiomic analysis of periatrial adipose tissue may be considered as a promising non-invasive method for predicting adverse outcomes of the catheter treatment, which opens the possibilities for planning and correction of patient management tactics after intervention.

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