Relationship of tgf-β1 and mthfr gene polymorphism with the development of varicose disease and its thrombotic complications

Aim. Identification the association of TGF-β1 and MTHFR genes with the development of lower extremityvaricose disease and its thrombotic complications.Material and methods. 161 patients with varicose disease (main group) were examined: 111 patientswithout thrombotic complications, 50 with phlebothrombosis. The control group included 155 conditionally healthy individuals. We studied the frequency of carriage of the G/G, G/C, C/C genotypes of thers1800471 polymorphism in the TGF-β1 gene and the C/C, C/T, T/T genotypes of the rs1801133 polymorphism in the MTHFR gene.Results. Among patients with venous thrombosis, the frequency of carriage of the heterozygous G/C genotype TGF-β1 gene and the mutant homozygous T/T genotype MTHFR gene was almost 4 times higherthan in control group (χ2>3,84; p<0,05; OR=3,9; 95% CI:1,64–8,98 and χ2>3,84; p<0,05; OR=3,1; 95%CI:1,11–8,49, respectively).Conclusions. The presence of the heterozygous G/C genotype of the TGF-β1 gene and the homozygousT/T genotype of the MTHFR gene has diagnostic and prognostic significance and greatly increases the riskof developing varicose disease and phlebothrombosis.

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