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CLINICAL AND LABORATORY FEATURES OF CONNECTIVE TISSUE DYPLASIA IN PATIENTS WITH UPPER GIT PATHOLOGY

Gulandom Zikriyaevna SHODIKULOVADepartment of Internal Medicine №3. Samarkand State Medical University, Uzbekistan, SamarkandDilshod Karimovich SAMATOVDepartment of Internal Medicine №3. Samarkand State Medical University, Uzbekistan, SamarkandOzod Vohidovich MIRZAEVDepartment of Internal Medicine №3. Samarkand State Medical University, Uzbekistan, SamarkandJahongir Zhamshedovich VOKHIDOVDepartment of Internal Medicine №3. Samarkand State Medical University, Uzbekistan, Samarkand

Zenodo (CERN European Organization for Nuclear Research)repository2023en

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Annotatsiya

The aim of the study was to study the state of endothelial function, connective tissue metabolism in patients with pathology of the upper gastrointestinal tract against the background of connective tissue dysplasia in order to develop a system for managing patients at the level of primary health care. As a result of the study, it was found that patients with pathology of the gastrointestinal tract associated with CTD had a decrease in the level of magnesium in the blood, activation of hyaluronidase, which contributed to an increased breakdown of the components of the extracellular matrix with an increase in the excretion of their decay products. Endothelial dysfunction is also noted, due to an imbalance in the NO system. The imbalance in the NO system, in turn, is determined by the overexpression of iNOS and the accumulation of ONO2-, inhibition of eNOS activity.

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Cutaneous Melanoma Detection and Management

Identifikatorlar

DOI: 10.5281/zenodo.8001971

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