THE ROLE OF ESTROGENIC DEFICIENCY IN THE DEVELOPMENT AND PROGRESSION OF GENITAL PROLAPSE
Negmajanov Bahodur BoltaevichSamarkand State Medical university Samarkand UzbekistanNasimova Nigina RustamovnaSamarkand State Medical university Samarkand UzbekistanJalolova Iroda AbdujabborovnaSamarkand State Medical university Samarkand Uzbekistan
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Our results of the study allowed us to establish that the mutant A allele and the A/A genotype of the rs9340799 polymorphism in the estrogen receptor gene ESR1 are associated with an increased risk of developing a severe degree of genital prolapse and can be considered as independent genetic markers that have a pathogenetic contribution to the aggravation of the disease, while the main genotype G/G is a protective marker that prevents the transition of the disease into a severe form.
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