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GENES OF POLYMORPHISM OF VASCULAR TONE AND ENDOTHELIAL DYSFUNCIA IN THE DEVELOPMENT OF PRE-ECLAMPSIA IN THE UZBEK POPULATION

Nishanova Firuza PulatovnaRepublican specialized scientific and practical medical center obstetrics and gynecology, Tashkent, UzbekistanKhegai Tatyana RudolfovnaRepublican specialized scientific and practical medical center obstetrics and gynecology, Tashkent, UzbekistanKarimova Lutfiya AzizovnaRepublican specialized scientific and practical medical center obstetrics and gynecology, Tashkent, Uzbekistan

Zenodo (CERN European Organization for Nuclear Research)repository2023en

ABI

Annotatsiya

Preeclampsia is a serious complication of pregnancy that affects the health of both mother and fetus. The aim of the study was to study the role of the most studied gene polymorphisms responsible for the regulation of vascular tone and endothelial dysfunction with the risk of preeclampsia. The results of the study showed the presence in the NOS3 gene structure of risk (G allele/GG genotype) and protective (T allele) markers in the development of PE. The carriage of the mutant allele T of the rs1799998 polymorphism of the aldosterone synthase gene is also associated with the risk of developing PE. Haplotype analysis of these loci revealed the presence of risky TG (P=0.02, OR=1.7) and protective CT (P=0.015, OR=0.21) haplotypes in the development of PE.

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Mavzular

Education, Innovation and Language Studies

Identifikatorlar

DOI: 10.5281/zenodo.8319793

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