Sharh maqola

Recent Update on the Protective Potentials of Resveratrol againstCisplatin-induced Ototoxicity: A Systematic Review

Fahad AlsaikhanDepartment of Clinical Pharmacy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Kingdom of Saudi ArabiaSaade Abdalkareem JasimMedical Laboratory Techniques Department, Al-Maarif University College, Al-anbar-Ramadi, IraqRia MargianaAndrology Program, Faculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaMaria Jade Catalan OpulenciaCollege of Business Administration, Ajman University, Ajman, United Arab EmiratesGhulam YasinDepartment of Botany, Bahauddin Zakariya University, Multan, PakistanAli Thaeer HammidComputer Engineering Techniques Department, Faculty of Information Technology, Imam Ja’afar Al-Sadiq University, Baghdad, IraqMakhzuna Tahsinovna NasretdinovaDepartment of Otorhinolaryngology No.2, Samarkand State Medical Institute, Amir Temur Street 18, Samarkand, UzbekistanAhmed B. MahdiAnesthesia Techniques Department, Al-Mustaqbal University College, Babylon, IraqBagher FarhoodDepartment of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, IranRazzagh Abedi‐FirouzjahCellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, IranTannaz JamialahmadiApplied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, IranAmirhosein SahebkarApplied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Current Medicinal Chemistryjournal2023en

ABI

Annotatsiya

INTRODUCTION: Although cancer treatment with cisplatin is effective, dose-dependent adverse effects such as ototoxicity occurs often, which limits its clinical use. The use of resveratrol may alleviate the cisplatin-induced ototoxic effects. This study is aimed to review the potential otoprotective effects of resveratrol against cisplatin-induced ototoxicity. METHOD: According to the PRISMA guideline, a systematic search was accomplished to identify all relevant scientific papers on "the role of resveratrol against cisplatin-induced ototoxicity" in different electronic databases up to May 2021. Fifty-five articles were screened based on a predefined set of inclusion and exclusion criteria. Eight eligible studies were finally included in the current systematic review. The in-vitro findings revealed that cisplatin administration significantly decreased the HEI-OC1 cell viability compared to the untreated cells; however, resveratrol co-treatment (in a dose-dependent manner) could protect HEI-OC1 cells against cisplatin-induced decrease in cell viability. RESULTS: Furthermore, the in-vivo finding showed a decreased value of DPOAE, and increased values of ABR threshold, ABR-I, ABR-IV, and ABR I-IV interval in cisplatin-treated animals; in contrast, resveratrol co-administration demonstrated an opposite pattern on these parameters. CONCLUSION: Thus, it can be mentioned that resveratrol co-treatment alleviates cisplatin-induced ototoxicity. Mechanically, resveratrol exerts its otoprotective effects through various mechanisms such as anti-oxidant, anti-apoptosis, and anti-inflammatory.

Hali tarjima qilinmagan

Mavzular

Hearing, Cochlea, Tinnitus, Genetics Oral health in cancer treatment Bioactive natural compounds

Identifikatorlar

DOI: 10.2174/0929867331666230724124013

Iqtiboslar va manbalar

0 ta iqtibos139 ta foydalanilgan manba

Koʻrsatkichlar — AkademScholar