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Polyphenols and Their Nanoformulations as Potential Antibiofilm Agents Against Multidrug-Resistant Pathogens

Modawy Elnour Modawy ElkhalifaFaculty of Public and Environmental Health, University of Khartoum, Khartoum, SudanMuhammad AshrafDepartment of Pharmacy, University of Malakand, Chakdara, Dir (L), KP, 18800, PakistanAlshebli AhmedFaculty of Public and Environmental Health, University of Khartoum, Khartoum, SudanAssad UsmanDepartment of Pharmacy, University of Malakand, Chakdara, Dir (L), KP, 18800, PakistanAlashary Adam Eisa HamdoonFaculty of Public and Environmental Health, University of Khartoum, Khartoum, SudanMohammed Ahmed ElawadFaculty of Public and Environmental Health, University of Khartoum, Khartoum, SudanMeshari G. AlmalkiPublic Health Department, Health Sciences College at Al-Leith, Umm Al-Qura University, Al leith, KSAOsama F. MosaPublic Health Department, Health Sciences College at Al-Leith, Umm Al-Qura University, Al leith, KSAL. N. NiyazovMedical Chemistry Department, Bukhara State Medical Institute Named After Abu Ali Ibn Sino, Bukhara, UzbekistanMuhammad AyazDepartment of Pharmacy, University of Malakand, Chakdara, Dir (L), KP, 18800, Pakistan

Future Microbiologyjournal2024en

ABI

Annotatsiya

The emergence of multidrug-resistant (MDR) pathogens is a major problem in the therapeutic management of infectious diseases. Among the bacterial resistance mechanisms is the development of an enveloped protein and polysaccharide-hydrated matrix called a biofilm. Polyphenolics have demonstrated beneficial antibacterial effects. Phenolic compounds mediate their antibiofilm effects via disruption of the bacterial membrane, deprivation of substrate, protein binding, binding to adhesion complex, viral fusion blockage and interactions with eukaryotic DNA. However, these compounds have limitations of chemical instability, low bioavailability, poor water solubility and short half-lives. Nanoformulations offer a promising solution to overcome these challenges by enhancing their antibacterial potential. This review summarizes the antibiofilm role of polyphenolics, their underlying mechanisms and their potential role as resistance-modifying agents.

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Mavzular

Antimicrobial Peptides and Activities Essential Oils and Antimicrobial Activity Antimicrobial agents and applications

Identifikatorlar

DOI: 10.2217/fmb-2023-0175

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