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Chemical Composition of <i>Artemisia Scoparia</i> and Their Bioactivities

Guziliayi KuerbanState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization and Key Laboratory of Plant Resources and Chemistry of Arid Zone Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences Urumqi 830011 PR ChinaAblajan TurakState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization and Key Laboratory of Plant Resources and Chemistry of Arid Zone Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences Urumqi 830011 PR ChinaNurmirza BegmatovS.Yu.Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan Tashkent UzbekistanJiangyu ZhaoState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization and Key Laboratory of Plant Resources and Chemistry of Arid Zone Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences Urumqi 830011 PR ChinaHaji Akber AisaState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization and Key Laboratory of Plant Resources and Chemistry of Arid Zone Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences Urumqi 830011 PR China

Chemistry & Biodiversityjournal2024en

ABI

Annotatsiya

Three undescribed sesquiterpenes (1-3), two enantiomeric pairs of monoterpenes (4a/4b-5a/5b), one alkyne (6), two known alkynes (7-8) and eight known coumarins (9-16) were isolated from the aerial parts extracts of Artemisia scoparia. The structures of these compounds were fully elucidated by their 1D and 2D NMR, HRESIMS spectral data analyses, and comparison with literature. The absolute configurations of compounds were determined by single-crystal X-ray crystallography (1), a comparison of experimental and calculated electronic circular dichroism (ECD) data (2-6). 15 showed moderate inhibitory activity with the NO release in LPS-induced RAW264.7 cells. 9-16 showed varying degrees of promoting melanogenesis and tyrosinase activity in B16 cells.

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Mavzular

Essential Oils and Antimicrobial Activity Phytochemistry and Biological Activities Sesquiterpenes and Asteraceae Studies

Identifikatorlar

DOI: 10.1002/cbdv.202400414

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