Design and development of green electrode using graphene oxide modified with L-hypip coated with iron NPs for enantioselective electro-organic cyanation in the presence of NaCl electrolyte
Annotatsiya
• -Accelerating the formation of chiral carbon-carbon bonds for efficient synthesis. • -Creating eco-friendly catalysts for sustainable chemical processes. • -Designing reusable electrodes for enhanced energy efficiency and longevity. • Employing NaCl as an inexpensive, readily available electrolyte and co-catalyst for reactions. This study presents the development of a cost-effective and eco-friendly electrode for the enantioselective electro-organic synthesis of ( R )-2‑hydroxy-2-phenylpropanenitriles 4(a-l) with yields ranging from 88 % to 98 %. The electrode is constructed using graphene oxide (GO) modified with (2S,3R)-3-hydroxypiperidine-2-carboxylic acid (L-Hypip) as a cheap enantioselective organic linker and coated with iron (Fe) nanoparticles, referred to as GO Hypip@Fe. This design aims to facilitate the efficient synthesis of ( R )-2‑hydroxy-2-phenylpropanenitrile derivatives 4(a-l). Sodium chloride (NaCl), a readily available and inexpensive electrolyte, is employed to enhance the electrochemical reaction rate. The electrode underwent thorough characterization and identification using SEM, EDS, XPS, XRD, TGA, BET, CV, and FT-IR analyses. Its cost-effectiveness and eco-friendly nature highlight its potential for sustainable electro-organic synthesis processes. The synthesized ( R )-2‑hydroxy-2-phenylpropanenitriles 4(a-l) were identified and characterized through melting point, 1HNMR, and CHN analyses.