Measuring the Efficiency of Purging by non-random Mating in Human Populations
R. LaurentUniversité Paris CitéLaure GineauIRD, MERIT, Université Paris Cité , 75006 Paris , FranceJosé UtgeEco-anthropologie (EA), Muséum National d'Histoire Naturelle, CNRS, Université Paris Cité , 75016 Paris , FranceSophie LafosseEco-anthropologie (EA), Muséum National d'Histoire Naturelle, CNRS, Université Paris Cité , 75016 Paris , FranceChan Leakhena PhoeungRodolphe Mérieux Laboratory, University of Health Sciences , Phnom Penh , CambodiaTatyana HegayLaboratory of Genome-cell technology, Institute of Immunology and Human genomics, Academy of Sciences , Tashkent , UzbekistanRobert OlasoCentre National de Recherche en Génomique Humaine (CNRGH), CEA, Université Paris-Saclay , 91057, Evry , FranceAnne BolandCentre National de Recherche en Génomique Humaine (CNRGH), CEA, Université Paris-Saclay , 91057, Evry , FranceJean‐François DeleuzeCentre National de Recherche en Génomique Humaine (CNRGH), CEA, Université Paris-Saclay , 91057, Evry , FranceBruno ToupanceEco-Anthropologie, Université Paris Cité , 75006 Paris , FranceÉvelyne HeyerEco-anthropologie (EA), Muséum National d'Histoire Naturelle, CNRS, Université Paris Cité , 75016 Paris , FranceAnne‐Louise LeuteneggerNeuroDiderotRaphaëlle ChaixEco-anthropologie (EA), Muséum National d'Histoire Naturelle, CNRS, Université Paris Cité , 75016 Paris , France
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Human populations harbor a high concentration of deleterious genetic variants. Here, we tested the hypothesis that non-random mating practices affect the distribution of these variants, through exposure in the homozygous state, leading to their purging from the population gene pool. To do so, we produced whole-genome sequencing data for two pairs of Asian populations exhibiting different alliance rules and rates of inbreeding, but with similar effective population sizes. The results show that populations with higher rates of inbred matings do not purge deleterious variants more efficiently. Purging therefore has a low efficiency in human populations, and different mating practices lead to a similar mutational load.
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