CO₂ - extraction of glycyrrhizic acid from licorice root: Optimization of extraction conditions using RSM

Extraction of GA (glycyrrhizic acid) from licorice roots was carried out utilizing SC-CO 2 with etilen as a dissolvable. Tests and recreations were assigned utilizing RSM. Licorice root extricate was analyzed by chromatography and AAS. The RSM plan was utilized to optimize the SCE factors and Glycyrrhizic Acid surrender. The most extreme Glycyrrhizic Acid surrender was watched beneath conditions of 10,9 MPa, 90,5 and 49,5 °C, 93 min and a stream of 1,69 and 1,49 ml/min CO 2 utilizing RSM, separately. Agreeing to RSM, the R 2 and adjusted R 2 model are 95,9% and 92,3% individually. The precision of the GA surrender demonstrate is affirmed by triplet tests, giving an normal extraction abdicate of 51,9 ± 1,19 %, individually, for RSM.

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