39P The possibility of predicting the effectiveness of treatment of soft tissue sarcomas on the basis of the properties of their immunologic microenvironment

To study the possibility of using the assessment of local cellular immunity factors for predicting the effectiveness of treatment of soft tissue sarcomas. The study included 42 patients with soft tissue sarcoma: 26 with primary tumours and 16 with recurrent tumours undergoing surgical treatment in the period 2016-2022. In all the patients, the intraoperatively obtained tumour tissues, peritumoral tissues and conditionally healthy tissues were studied to assess the local immunity parameters and conditionally healthy tissues corresponding to the resection lines (114 samples in total). Tissue samples were homo-genotyped, and lymphocyte subpopulations were determined on a flow cytometer. The characteristics of the lymphocytic microenvironment of soft tissue sarcomas in connection with the clinical effect of complex treatment of patients were studied In primary sarcomas, the development of event-free survival more than 12 months after surgery corresponded to a higher content of NK-cells in the tumour tissue a higher ratio of NKT-lymphocyte levels in the peritumoral zone and tumour, as well as a lower level of NKT-lymphocytes in the peritumoral zone and tumour. In relapsed sarcomas, short event-free survival was associated with high levels of choli, as well as a lower level of Tregs than in patients with event-free survival of less than 12 months. DN-cells in the tumours and the ratio of the proportion of CD3+-lymphocytes in the peritumoral zone and tumour. All the above-mentioned The differences were statistically significant (p < 0.05). The clinical effect of complex treatment of soft tissue sarcomas is related to the initial state of the immunological microenvironment of the tumours; a number of indicators of local cellular immunity can be considered as prognostic factors differing for primary and recurrent sarcomas.

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