EVALUATION OF EFFICACY OF ANTIHYPERTENSIVE THERAPY FOR PSYCHOEMOTIONAL STATUS IN PATIENTS WITH ARTERIAL HYPERTENSION

Objective: To evaluate the effectiveness of antihypertensive therapy on the level of personal, reactive anxiety and depression in patients with hypertension (AH). Design and method: The study included 75 patients with AH aged 39-69 years (average age 54 ± 3 years). During the study, the causes of symptomatic AH, baseline antihypertensive therapy was optimized. AH was diagnosed by daily monitoring of blood pressure (DMBP) using the TONOPORT device (Germany) according to the standard method. At baseline and in the course of 3-month antihypertensive therapy (AHT) with valsartan (160 mg per day) and indapamide 2.5 mg per day, the level of personal and reactive anxiety on the State-Trait Anxiety Inventory, STAI and depression on the Zung Self-Rating Depression Scale were determined. Results: At baseline, the indicators of personal and reactive anxiety in patients with AH were noticeably higher (27 ± 1 point and 26 ± 2 points). At the same time, the indicators of reactive and especially personal anxiety closely correlated with the average daily indicators of systolic BP (r - 0.47 at p < 0.05 and 0.54 at p < 0.01). Insufficient decrease in BP at night was more clearly associated with the severity of depression and anxiety detected on the Zung Self-Rating Depression Scale (r -0.39, at p < 0.05). The increase in personal anxiety was clearly associated with an increase in the average daily variability of systolic BP. As a result of the combined AHT, a significant decrease in the scores on the used scales was observed. The measures of personal and reactive anxiety were 22 ± 2 and 21 ± 1 point, respectively, (p < 0.01 from baseline). The increase in personal anxiety was clearly associated with an increase in the average daily variability of systolic BP (r -0.46, p < 0.05). Conclusions: The degree of arterial hypertension and daily variability is associated with an increase in the level of anxiety and severity of depressive disorders in patients with AH. Adequate AHT contributes to the improvement of psychoemotional status indicators in patients with AH.

Hali tarjima qilinmagan