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Development of Eutectics of Pioglitazone with Citric Acid and its Effect on Crystallite Properties and Dissolution

Mouli Das. [email protected]Shibashis Panigrahy. [email protected]Rasmita Dash. [email protected]Rudra Narayan Sahoo. [email protected]Rakesh Swain. [email protected]Souvik Nandi. [email protected]Sk Habibullah. [email protected]Tanisha Das. [email protected]Subrata MallickSchool of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to be University). [email protected]

Acta chimica slovenicajournal2024en

ABI

Annotatsiya

Eutectics of pioglitazone were developed using citric acid (CA) as the co-former, and the effect on crystallite properties and dissolution has correspondingly been studied. Pioglitazone-citric acid eutectics (PC1, PC2, PC3, and PC4) in different molar ratios (3:1, 3:2, 1:1, and 3:4 respectively) were prepared by simple solvent evaporation method. Difference in dislocation density and strain value of the eutectics were observed, and the maximum strain value of PC1 might be due to the highest deformation activity compared to PC2, PC3, and PC4. Carbonyl-thiazolidine or carboxyl-pyridine weak bond formation might be the reason of producing eutectics of PGZ-CA rather than cocrystal with a docking score of - 2.2 Kcal/M. Likewise, lowest particle size was found with PC1 rather than that of pure PGZ and other eutectics. PC1 demonstrated highest dissolution of drug (68 %) rather than other eutectics (54 to 61 %) and PGZ (44 %) after 360 min.

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Mavzular

Crystallization and Solubility Studies Veterinary medicine and infectious diseases Enzyme Structure and Function

Identifikatorlar

DOI: 10.17344/acsi.2024.8793

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