New Bioactive Coordination Polymers With Sulfosalicylic Acid: Synthesis, Characterization, Cytotoxicity, Antiradical Activity, and Adsorption Properties

ABSTRACT Three new coordination polymers (CPs) formulated—[Cu(5‐SSA)Cu 2 (MEA) 2 ]·2H 2 O ( 1 ) (where 5‐SSA = 5‐sulfosalicylic acid, MEA = monoethanolamine); [Mn(SSA) 4 (H 2 O) 2 ] n (MEA)(H 2 O) ( 2 ); [Na (SSA)]MEA ( 3 )—have been prepared and characterized by various spectroscopic techniques, elemental analysis, and single‐crystal X‐ray diffraction method. In 1 , coordination numbers of both copper ions are six with octahedron geometry. Further, this compound has complicated intermolecular H‐bonds in the polymeric structure that incorporate polymeric chains into 3‐D networks. Compound 2 also exhibits a polymeric bimolecular chain structure and features two intramolecular hydrogen bonds, both having the same graph‐set notation of S11(6) in the structure. Further, it is a supramolecular compound (clathrate or host‐guest complex) with inclusion of monoethanolamine (MEA) and water. Similarly, 2‐D polymeric layer structure of compound 3 with strong H‐bonds generated a 3‐D network. All these CPs were explored to study their cytotoxicity, antiradical activity, and adsorption properties. The cytotoxicity results indicate that compound 1 has acute toxicity in the mice, characterized by adverse effects and a significant mortality rate. Further, the average lethal dose (LD50) of the compounds 1–3 is estimated 546, 708, and 750 mg/kg, respectively. In case of antiradical activity, the CPs 2 and 3 have high antioxidant radical forming (ARF) capability. The adsorption of N₂ at low temperatures was evaluated using an Autosorb device and the measured P 0 value at 77 K was 101.3 kPa. In addition, the surface area of these compounds were also determined by Brunauer–Emmett–Teller (BET), which affirmed 311.9, 526.69, and 349.8781 m 2 /g for compounds 1–3 , respectively. The nitrogen adsorption data revealed that compounds 1 and 2 contain only mesopores, while compound 3 consists exclusively of micropores. Barrett–Joyner–Halenda (BJH) method was explored to determine mesopore volume with values of 0.171459, 0.808656, and 0.11969 cm 3 /g for compounds 1–3 , respectively.

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