Metabolite profiling, <i>in vitro</i> biological activities, and <i>in silico</i> molecular docking analysis of <i>Silene kuschakewiczii</i>
Nilufar Z. MamadalievaFaculty of Medicine, Alfraganus UniversitySohaib KhatibCollege of Agriculture and Environmental Sciences, University Mohammed VI PolytechnicNilufar SalohiddinovaTashkent Pharmaceutical InstituteFazliddin JalilovFaculty of Medicine, Alfraganus UniversityDilafruz Nematilla kizi JamalovaInstitute of Botany of the Academy Sciences of UzbekistanMai AlbaikDepartment of Chemistry, Batterjee Medical CollegeGokhan ZenginDepartment of Biology, Science Faculty, Selcuk University
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, mainly flavonoids and oleanane-type triterpenes. Among them, the major compounds were schaftoside-2-O-glucoside and saponarin. The crude methanol extract also showed the ability to scavenge free radicals effectively (DPPH: 13.12 mg TE/g; ABTS: 53.42 mg TE/g). In addition, it exhibited remarkable inhibitory activity on the studied enzymes (AChE: 2.03 mg GALAE/g; BChE: 1.67 mg GALAE/g; tyrosinase: 61.42 mg KAE/g; amylase: 0.19 mmol ACAE/g; glucosidase: 0.57 mmol ACAE/g) and a strong anti-proliferative effect against MCF-7 cancer cells (IC50: 16.44 μg/mL). Molecular docking studies showed that the major compound saponarin had the strongest affinity for interaction with the active site of tyrosinase, with a docking score of -12.5 kcal/mol.
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