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Four New Diterpenoid Alkaloids From <i>Delphinium iliense</i> Huth

Ahmatbeck SamanbayState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences Urumqi P. R. ChinaNurfida AblajanState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences Urumqi P. R. ChinaWenjuan XueState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences Urumqi P. R. ChinaJiangyu ZhaoState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences Urumqi P. R. ChinaXueying LuState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences Urumqi P. R. ChinaШ. Ш. СагдуллаевS. Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of Sciences of the Republic of Uzbekistan Tashkent UzbekistanBo ZhaoState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences Urumqi P. R. ChinaMaidina HabasiState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences Urumqi P. R. China

Chemistry & Biodiversityjournal2025en

ABI

Annotatsiya

-diterpenoid alkaloids, sinchianidines A-D (1-4), together with eight known diterpenoid alkaloids (5-12), were isolated from the whole plant of Delphinium iliense Huth (Ranunculaceae). Their structures were established by extensive spectroscopic analyses, while the absolute configurations of sinchianidine A (1) and sinchianidine C (3) were determined by experimental electronic circular dichroism spectra comparison. Biological activity evaluations revealed that sinchianidines C and D (3 and 4) demonstrated significant pain inhibition (78.16% and 72.54%, respectively) in acetic acid-induced writhing tests of mice at a dose of 5 mg/kg. Compounds 1-4 showed no significant inhibitory activity on the Human Ether-à-go-go-related gene and CaV3.1 (T-type calcium) channels. Additionally, all isolates showed no significant cytotoxicity against Hela, HCT8, and MCF7 human cancer cells in vitro.

Hali tarjima qilinmagan

Mavzular

Plant-based Medicinal Research

Identifikatorlar

DOI: 10.1002/cbdv.202500331

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