SYNTHESIS OF (E)-5-(3,4-DIMETHOXYBENZYLIDENE)-3-METHYL-6,7-DIHYDROPYRROLO[1,2-a]THIENO[3,2d]PYRIMIDIN-9(5H)-ONE
Anvarjon BURONOV Azizbek NASRULLAEVPhD student at Sharof Rashidov Samarkand State University, DSc student at Sharof Rashidov Samarkand State UniversityNie LIFEI Khurshed BOZOROVProfessor at The Xinjiang Technical Institute of Physics & Chemistry. CAS, Professor at Samarkand State University named after Sharof Rashidov Professor at The Xinjiang Technical Institute of Physics & Chemistry. CASHaji Akber AisaProfessor at The Xinjiang Technical Institute of Physics & Chemistry. CAS
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(E)-5-(3,4-Dimethoxybenzylidene)-3-methyl-6,7-dihydropyrrolo[1,2-a]thieno[3,2-d]pyrimidin-9(5H)-one (AR-109) was synthesized in two steps from ethyl 3-amino-5-bromobenzo[b]thiophene-2-carboxylate (AT-2). 1H and 13C NMR, HRMS confirmed the structure. Increased reaction temperature and duration significantly improved yield. These derivatives hold promise for pharmaceutical and material applications.
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