ABS0960 THE ROLE OF BMP-7 IN THE PROGRESSION OF SPINAL STRUCTURAL CHANGES IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS
Annotatsiya
<h2>Abstract</h2><h3>Background:</h3> Progressive spinal lesions in axial spondyloarthritis (axSpA) are often caused by the formation of syndesmophytes, bone outgrowths resulting from chronic inflammation. Bone morphogenetic proteins (BMPs) are known for their ability to induce ectopic cartilage formation and bone development. Among BMPs, BMP-7 is believed to play a crucial role in skeletal development and repair. However, the relationship between BMP-7 levels, disease activity, and the progression of spinal structural changes in axSpA patients is still poorly understood. <h3>Objectives:</h3> To study the role of Bone Morphogenetic Protein–7 (BMP-7) in patients with axial spondyloarthritis and its potential as a biomarker for spinal structural changes. <h3>Methods:</h3> This study was conducted between 2022 and 2024 at the 3rd City Clinical Hospital of Tashkent and the 1st City Hospital named after Abu Ali ibn Sina. A total of 88 patients diagnosed with axial spondyloarthritis according to the ASAS modified criteria (2009) were included. Patients were divided into two groups, group I-42 patients with axSpA, exhibiting signs of syndesmophytes and ankylosis, group II- 46 patients with axSpA, without signs of syndesmophytes. A control group of 30 healthy volunteers, matched by age and gender, was also included. The average age of patients in Group I was 46.4±9.4 years, while in Group II, it was 38.2±6.1 years. Clinical, laboratory, and imaging studies were performed on all participants, including measurement of BMP-7 levels. <h3>Results:</h3> Both groups showed high disease activity. The pain intensity, measured on the Visual Analog Scale (VAS), was 7.0±1.1 in Group I and 6.3±0.8 in Group II (p<0.05). The BASDAI scale for disease activity indicated a high level of activity in Group I (5.6±1.0 points) and moderate activity in Group II (5.1±0.7 points). The ASDAS scale confirmed this trend, with Group I showing a high level of disease activity (4.9±1.3 points) and Group II showing moderate activity (4.8±1.1 points, p<0.05). The mSASSS index, reflecting the degree of spinal structural changes, was 28.1±3.6 in Group I and 7.3±0.9 in Group II. The BMP-7 level was significantly higher in Group I (139.3±16.8 ng/mL, p<0.05) compared to Group II (69.8±6.2 ng/mL), and both groups had significantly higher BMP-7 levels compared to the control group (11.1±1.5 ng/ml). <h3>Conclusion:</h3> The study revealed a significantly elevated BMP-7 level in patients with syndesmophytes, suggesting that BMP-7 may influence the progression of bone-structural changes in the spine in axSpA patients. Lower BMP-7 levels in patients without syndesmophytes in Group II also indicate a potential role of this marker in modulating the rate of spinal structural progression. BMP-7 levels could serve as a biomarker for assessing the rate of progression of spinal structural changes in patients with axial spondyloarthritis. <h3>REFERENCES:</h3> [1] Mahmoud, A., Fayez, D., Gabal, M. M., Hamza, S. M., & Badr, T. (2016). Insight on Bone Morphogenetic Protein 7 in Ankylosing Spondylitis and its association with disease activity and radiographic damage. Electronic physician, 8(7), 2670–2678. https://doi.org/10.19082/2670. <h3>Acknowledgements:</h3> <b>NIL</b>. <h3>Disclosure of Interests:</h3> <b>None declared</b>. © The Authors 2025. This abstract is an open access article published in Annals of Rheumatic Diseases under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Neither EULAR nor the publisher make any representation as to the accuracy of the content. The authors are solely responsible for the content in their abstract including accuracy of the facts, statements, results, conclusion, citing resources etc.